Both players picked up minor hamstring injuries in last weekend's 3-2 win over Hertha Berlin but did return to full training on Thursday.
However, Guardiola does not want to rush either man back into action, given Bayern have a Champions League game against Viktoria Plzen to come on Tuesday.
"Toni is a bit further along than Arjen," the former Barcelona boss told reporters on Friday. "They both trained yesterday.
"Perhaps they are not fit tomorrow, but next Tuesday or next Saturday they will be fit."
Guardiola also admitted that the trip to Hoffenheim has also probably come a tad too soon for defender Dante, who has been struggling with an ankle problem.
"He has trained well, although there are still little problems," the Catalan coach explained.
Bayern's meeting with Hoffenheim at the Rhein-Neckar-Arena is scheduled to get under way at 15:30CET.
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