The Blaugrana have won their last 19 Liga games at Camp Nou since a Cristiano Ronaldo double secured a 2-2 draw for the Blancos over a year ago, and Cruyff thinks that formidable record will help the hosts secure a crucial victory.
"Respect to Madrid because they always have a very strong team," the 66-year-old told Sport.
"But there are many influencing factors, and at home, Barcelona are always favourites."
Cruyff also lent support to Barca's Brazilian forward Neymar, who has come in for criticism from some quarters after scoring just three goals in thirteen appearances since his €57 million summer switch from Santos.
"Even a blind man can see what a great player he is," Cruyff said
"Anyone who does not think he is a good player does not know the game."
Yet the Dutchman still chose a pair of familiar names as the men most likely to prove decisive in Saturday's tussle.
"Barcelona and Madrid depend on Messi and Ronaldo," he added.
"Both sides have lots of quality and both have players who can influence the game, but those two make the goals and that makes the difference."
